AM404 acts on the transient receptor potential vanilloid 1 (TRPV1) and cannabinoid 1 (CB1) receptors in the midbrain and medulla ( in vivo and in vitro whole-cell patch-clamp recordings with rats, wherein the acetaminophen metabolite AM404 directly induces analgesia via TRPV1 receptors on the spinal dorsal horn ( Acetaminophen does not possess any anti-inflammatory activity, because it is a very weak inhibitor of COX and does not inhibit neutrophil activation ( The purpose of this review was to summarize the previous and new issues related to the analgesic mechanisms of acetaminophen and discuss our understanding that acetaminophen metabolite AM404 also acts on the spinal dorsal horn and induces analgesia in inflammatory pain conditions
Results LCMS/MS-based quantitative analyses for site- and acyl group-selectivity of human sirtuins on acylated nucleosomes We have previously developed artificial catalyst systems composed of a nucleosome-binding catalyst (8DMAP) and acyl donors, including an acetyl donor (3NMD8R, 1 ) and a malonyl donor (3Mal8R, 3 ) 20 (Fig
doi: 10.1124/jpet.108.140533
Liao D, Yang G, Yang Y, Tang X, Huang H, Shao J, et al
Cancer 12 , 741752 (2012)
